In part on2 it is twenty-eight years since the rage virus escaped a biological weapons laboratory, now, still in a ruthlessly enforced quarantine, some have found ways to exist amidst the infected. One such group lives on a small island connected to the mainland by a single, heavily-defended causeway. When one member departs on a mission into the dark heart of the mainland, he discovers secrets, wonders, and horrors that have mutated not only the infected but other survivors as well. The Bone Temple sees Dr. Kelson finding himself in a shocking new relationship - with consequences that could change the world as they know it - and Spike's encounter with Jimmy Crystal becomes a nightmare he can't escape.